- Peter Diamandis discusses the Life Force supplement products and their goal to benefit from progress in the biotech world.
- Dr. Hector López is the head scientific and innovation advisor for LifeForce and explains the importance of NMN (nicotinamide mononucleotide).
- NMN is a precursor to NAD (nicotinamide adenine dinucleotide) and plays a role in increasing NAD status in the body.
- There are different versions of NMN available, and it is important to understand which ones are effective.
- NMN is one step away from becoming NAD and has potential benefits for age reversal and healthspan.
- The body has various pathways and enzymes to convert different NAD precursors into NAD.

- The sirtuins stabilize the epigenome and regulate gene expression.
- NAD powers the sirtuins and is important for DNA repair.
- NAD levels decrease as we age, making it important to support sirtuin function.
- NMN is taken to increase intracellular NAD levels.
- NMN stability and reliability are important factors in choosing a product.
- NMN may have challenges with oral bioavailability and methylation status.
- Offensive and defensive strategies are used to improve NAD status.
- NMN supplementation has been shown to increase blood NAD levels in human clinical trials.

- NAD levels in the blood can be increased by 150-300% by taking 250-500mg of NMN per day.
- Berberine is added to the product as a natural alternative to metformin for improving glycemic control and insulin sensitivity.
- Reducos, an extract from white mulberry leaves, is included to mimic the effects of a carbos inhibitor in regulating blood glucose levels.
- Spermidine, a polyamine, is added to support DNA repair, autophagy, and protein translation.
- Human studies have shown that spermidine can improve cognitive function in older adults with mild dementia.
- Peak Healthspan and Peak NMN work together to increase NAD levels and promote healthy lifespan activities.

- The speaker recommends starting with 3 capsules of peak NMN product per day, but suggests breaking them up more in the PM side of the day.
- Taking 2 capsules with the largest meal can help decrease insulin and glycemia spikes.
- Taking 1 more capsule at lunch or dinner is also recommended.
- The speaker emphasizes the importance of understanding the various components and how they work together for increasing vitality and longevity.
- Both the speaker and Hector are involved in LifeForce and believe in its benefits.
- The speaker expresses enthusiasm for the current time and the desire to make the most of every second.

- Peter Diamandis discusses LifeForce's goal to benefit from biotech progress with their Life Force supplement products.
- Dr. Hector López explains the importance of NMN (nicotinamide mononucleotide) as a precursor to NAD (nicotinamide adenine dinucleotide) and its potential benefits for age reversal and healthspan.
- Different versions of NMN are available, and understanding their effectiveness is crucial.
- NAD powers sirtuins, which stabilize the epigenome and regulate gene expression, and is important for DNA repair.
- NMN supplementation can increase intracellular NAD levels and has shown to do so in human clinical trials.
- The product also includes berberine for glycemic control, Reducos for blood glucose regulation, and spermidine for DNA repair and cognitive function improvement.
- The speaker recommends specific dosages of the product for optimal results.
- Understanding the components and their synergy is essential for increasing vitality and longevity.

Can we slow, stop, or even reverse the effects of aging? Lifeforce co-founder Dr. Peter Diamandis sits down with physician, scientist, and supplement expert Dr. Hector Lopez to take a closer look at the NAD precursor that has longevity researchers abuzz: NMN. You’ll learn why NAD is key to longevity, and how our cutting-edge Peak NMN™️ was formulated to maximize this essential compound.

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This is the third video in a sequence of videos talking about the Life Force supplement products.

Again, full disclosure, while I'm a medical doctor, I'm not a practicing physician, and I am a co-founder of Life Force.

And along with Tony Robbins, the author of this book, Life Force, How New Breakthroughs in Precision Medicine Can Transform the Quality of Our Life and Those You Love.

And coming out of this book, Tony and I really wanted to create a set of products that would make it easy for people to benefit from this incredible period of progress we're seeing in the biotech world.

We turned to 1 particular physician and scientists to help us orchestrate this, and that's Dr.

López is head scientific and innovation advisor for LifeForce, chief medical officer and co-founder of 2 groups, Center for Applied Health Sciences, and also Supplement Safety Solutions.

He's the creator of a wide range of supplements and ingredients, working on this field for 15 to 20 years.

And in this video, I want to talk about something that a dear friend, Dr.

So, Hector, good afternoon, first of all.

HECTOR PEREZ-RODRIGUEZ Hey, good afternoon.

Yeah, no, a pleasure and great to be on with you as well.

David Sinclair, who heads genomics at Harvard Medical School, first read his book called Lifespan years ago.

He is involved with me in my venture fund, and I just love his work.

And really, I credit him to a large degree with popularizing the idea not of just longevity or health span, but the idea of age reversal.

Can we in fact slow, stop, or perhaps even reverse aging?

And he talks about in his work, the things that he's doing to remain young.

And frankly, he looks 20 years younger than his chronological age.

And 1 of the things he talked about in his book that he gives credit to this and that his 80 plus year old dad is taking is NMN.

And then I wanna talk about some of the work that you and Tony and I did, which is where the heck do you go buy it?

Because if you look on the web, there's like 100 different versions of NMN.

So peak NMN was a product that I felt we wanted to go as, as you can see is sort of a common motif with all of the Lifeforce products.

We tend to go above and beyond the call of duty in terms of, you know, the problem to solve, the need states, the features and benefits for consumers.

So someone looking for NMN, we want to make sure that we're able to buttress NMN with some other unique molecules and compounds that could potentially amplify NMN's ability to not only to increase NAD status, but even go beyond that and add some other features by targeting some other biochemical and molecular pathways that we know are associated with with healthspan as geroprotectors in other animal models as well as in some very early preclinical work in humans.

So first of all I mean NMN is an acronym standing for?

So, why is NMN viable in the body in the first place?

Yeah, so it's a precursor to NAD, which is nicotinamide adenine dinucleotide.

But I think this is a good place to start in terms of an NAD primer, because we'll be able to actually see the NMN molecule here.

And you'll be able to also see another commonly used precursor in the field in someone's goal to try to improve or increase their NAD status, or the amount of NAD that they're able to produce or they're able to secure in their cells in their body.

So NAD, we start with NAD, it is 1 of the oldest molecules on Earth.

It's really central as a really as a redox coenzyme for being able to move electrons.

So it's central to really almost all metabolism.

Well over 500 chemical reactions that are critical.

Without it, you know, life on earth wouldn't exist.

I think of it as the energy currency inside the cell, right?

Or at least it's part of the battery that allows you, yep, to get to that energy currency, to get to ATP.

Yeah, without it, you couldn't make ATP, for example, right?

But it also has another important function is that NAD is used as a substrate.

So on the 1 hand, it's just used to pass along electrons and what we call oxidation reduction reactions, like the electron transport chain, for example, in the mitochondria.

So and of course, that's critical to be able to convert all the chemical energy and all that are stored in all the bonds of the food that we eat, you know, the proteins, the carbohydrates and lipids, and be able to get it all the way down through the Krebs cycle.

And eventually, we have to take all of those electrons from all those bonds that we've broken from all the nutrients we've consumed, we need to be able to find an effective way to deliver those into the mitochondria to then eventually carry those along the chain and make ATP as the end product along with water, because of oxygen being the final hydrogen electron acceptor.

But NMN, you can see here, is this molecule.

So it's nicotinamide, which is this portion of the molecule, right, is nicotinamide.

If you add a sugar to it called ribose, then you have NR, which is nicotinamide riboside.

But you see the difference between NR and NMN?

So this is known in biochemistry, in the biochemical world, this is known as a nucleoside.

And once you add a nucleoside as a base, which is this nicotinamide component or moiety here, this is the sugar, together it's a nucleoside.

When you add the phosphate to it, it now becomes very charged as a molecule, and it's now a nucleotide.

And NMN is essentially 1 step away from becoming NAD, which is ultimately what everyone is after when we're trying to improve cellular NAD status.

So you could say NMN is a step closer than NR to NAD.

Now there's a lot of controversy still that to be honest, hasn't completely been worked out about whether, you know, can NMN be, can there be cellular uptake of NMN?

There's some speculation of some transporters, some SLC transporters that have been identified in some experimental models, but it hasn't really been duplicated or replicated by other groups.

So there's still controversy over whether it exists or not.

And the way I see it, the way me and my partners see it that are doing work in this area is we're kind of agnostic a little bit to your choice of NAD precursor.

Because your precursors could be NMN, it could be NR, It could just be this base here, just the nicotinamide, which is, which is found over here.

The body has a way to take all of these molecules, no matter which ones they are.

And that's the genius of the biochemical machinery in our body is, you know, an ad is so important, and so critical to life, because the body has numerous salvage pathways and enzymes to make NAD, whether you have NR in the cell, whether you have NMN in the cell, whether you have nicotinamide, or just straight up niacin, which really looks a lot like nicotinamide, except there's a hydrogen group on there, makes it an acidic, a little more acidic, but it's basically niacin and niacinamide are interchangeable.

Let me digress 1 second about the importance of NAD in the cell.

Sinclair wrote about is the notion that NAD plus, NAD is used by the 7 sirtuins to do a number of things that are critical.

So it's really the sirtuins are making sure that the right genes are on and the right genes are off.

What I tell people is listen, you know, end of the day, when you're born at age 0, at age 40, at 60, 80, 100, you got the same genes.

Why do you look different at birth or at 21?

It's the epigenome, what genes are on and what genes are off.

And so making sure that your epigenome that sirtuins are functioning properly is critically important.

But the sirtuins have an additional function that's powered by NAD, which is DNA repair.

And as you're getting older, your sirtuins that are powered by NAD are having you do more and more DNA repair because we're around smoke, we're around ionizing radiation, we're getting older.

And so imagine that your sirtuins are spending more and more time repairing DNA and less and less time, you know, sort of keeping the epigenome in place.

And imagine if at the same time, your supply of NAD, which is powering the sirtuins, is dropping in your cells.

And as you well know, Hector, our NAD levels drop by more than 50% as we age.

And so making sure that your sirtuins have all of the, you know, the food, the ingredients they need to, to operate at peak performance is, is critical, especially as we get older.

And that, and that's what, with this next slide here, talks about how pleiotropic NAD really is and and how it can influence all those functions.

Everything from critical metabolic pathways, being able to basically keep the lights on as energy currency, to DNA repair, to epigenome stability and integrity, to chromatin remodeling, which is part of what happens when the epigenome either gets damaged or when it's functioning correctly.

The chromatin is getting remodeled and the histones are getting mobilized in a way that opens up the DNA for certain genes to be, to your point, turned on when they need to be turned on for the type of cell it is and the function it's performing, or when those genes need to be turned off or repressed and silenced.

So the reason we take NMN is to increase our intracellular NAD levels, just to be extremely clear.

So 1 of the things I want to I want to get to for a moment is, and we talked about this in our book, life force, that when we looked at NMN on the marketplace, And in fact, you have labs that test products, right?

So you bring all kinds of nutraceutical products in and you test is what they say is in there, there, and is it active and is it safe and so forth.

Can you talk 1 second about the stability of NMN and also the, you know, what the different range of products are out there, which is why we felt compelled to sort of create our own life force version of NMN.

So NMN is a molecule because you saw that it's got a phosphate group, it's also got that sugar, it can be cleaved off, it can it can become very unstable under certain conditions.

So we made sure to scour really the earth in terms of who has the most stable, reliable NMN as a source, as a raw material that could be utilized for the peak NMN product for life force.

And really what we found was a particular manufacturer that takes unique care at multiple crystallization steps to make sure that The pH is controlled, the temperature is controlled, and the moisture level is controlled.

All 3 of those things, or any of those 3 things, can dramatically impact the degradation rate of NMN.

And it's probably why so many products on the market, when they are tested independently through GC mass spec or HPLC mass spec, it's probably why so many fail after very short periods of time of manufacture.

The 1 that we utilize, for example, has third-party independently verified 24-month stability.

And that's at typical room temperatures, even a little beyond room temperature and ambient moisture, as long as it's maintained within the bottle.

So that's very impressive and certainly bodes well for us having at least if you want reliable NMN that you know is going to test out every time batch to batch, that was important for us.

Fung So some of the challenges, right, with using any of these precursors, we talked about it already, the stability, reliability, but also the oral bioavailability, potentially because of the size and the polarity of the molecule.

The fact that it may burden your methylation status a little bit.

We do know that methyl groups are pulled and utilized in order for the body to handle what comes after NAD, after NAD is consumed and used by either sirtuins or some of those DNA repair PARP enzymes that you talked about before.

And then there's this other issue of dealing both offense and defensively to make sure that you can improve NAD status, right?

So we want to play on both sides of the ball, if you will.

Offensively, we know that's the easy thing to do is provide more precursor.

But also what we did is in combining peak NMN with peak healthspan, the other life force product, what we're doing is increasing the enzymes that allow you to go from the raw material precursor of NMN or even niacin or niacinamide that you might have in your background diet, and make sure that you can make more of the end product more NAD.

That's on the offensive side of the ball.

On the defensive side of the ball, we wanted to use ingredients that could potentially modulate or limit the overconsumption and depletion of NAD by some of these enzymes that are found on the outside, usually of white blood cells.

So whenever there's a lot of inflammation, systemic inflammation, when there's metabolic damage or metabolic sort of syndrome, these enzymes tend to get upregulated and they overconsume NAD.

So here's a nice sort of metabolic map, if you will, of the pathways of what the body does to make NAD here in the center.

So you can see that there's this classic sort of price handler pathway where you can consume nicotinic acid or niacin.

That's the flushing niacin that you can also supplement with or can be found in the diet.

That actually gets consumed and gets converted into nicotinic acid mononucleotide.

It's a similar version to NMN, but not quite NMN.

And then it gets transformed into another secondary metabolite.

And then finally, so you're talking about 3 enzymatic steps away from getting to NAD.

Whereas if you consume NMN, this is what I think, you know, in talking to Dr.

Sinclair and David and hearing and seeing his rationale, this is what he says, look, you're only 1 step away, right?

You only need to have this 1 enzyme act on NMN to get to your NAD, end product.

The potential challenge there is that it's possible that the body and even the microbiome in the gut modifies this NMN and you kind of get back up here or back up here or you get here to nicotinamide.

Either way, the nice thing about using NMN is you're going to find your way, you know, all roads lead to Rome, you're going to find your way to NAD, right?

So we're going to still play offense regardless with NMN.

I am, I am curious, how much of this is on faith and how much are we actually measuring intracellular increases in NAD levels?

I mean, the old adage around, you know, you pee away most of your supplements.

Any thoughts here or where the science is?

Yeah, Well, what's great about this is we have human clinical data now We're up to 7 there's 7 human clinical trials that have been published already in the public domain on NMN supplementation in humans What they in summary what all of them have basically told us is you can reliably increase the amount of blood, whole blood NAD levels.

So the amount of NAD you can measure in your blood in humans, and that's coming mostly from white blood cells in the blood, you can increase it by 150 to 300%.

Just by using 250 to 500 milligrams a day of NMN.

Yeah, and what's nice is that's corroborated by other, like almost 15 to 20 studies by NR as well.

And if you look back into the literature, of course, a lot of the, you know, and our manufacturers, etc, don't necessarily like that.

But you look at niacin and niacinamide in human models of mitochondrial myopathy, you can increase the amount of NAD in muscle, not just in blood, but in muscle of those patients with mitochondrial myopathy, they're starting off with very low levels and muscle because of genetic disorders, they can actually end up increasing the amount of muscle levels by 500% with just a dose of 500 milligrams a day.

Let's talk about playing offense and defense.

Those are available on the web, but you've added a couple of other components here, which I was fascinated as to why Yeah, take it away.

So here we have the supplement facts panel is just a quick reference guide on the right.

So we We did add berberine We added berberine because look berberine works through a very similar mechanism of action as metformin.

And so we wanted to have at least a natural product alternative for geroscience enthusiasts, geroprotective, someone looking for a geroprotective product to be able to get access to a natural product alternative.

So Burberry is there for all the things we already know it does, but even if you're not, even if you're still unsure about the longevity benefits, because ITPs failed to find a median or a maximal lifespan extension, I believe, but there've been some other studies published where there have been lifespan extensions in animal longevity and lifespan increases with berberine.

What we know is berberine has human clinical data that even at these doses, at the dose we include here, you can improve glycemic control.

So you can improve how your body handles carbohydrates when you do consume them.

And insulin sensitivity at both the liver and the muscle, which are very important.

So we have berberine here for that reason.

The other 1 that I think is kind of a pretty sophisticated way that we were all able to get around the the the ITPs found that a carbos, which is a drug that was FDA approved for type 2 diabetics and pre-diabetics.

For what it does is it's an inhibitor of the alpha amylase enzyme.

It's basically the enzyme found in both saliva and in the gut that breaks down starch, right?

It's kind of like a starch blocker, right?

The issue with a carbose is that at high doses as you can imagine if you don't break down starch in the upper part of the gut, and it gets to the distal part of the gut, you know, you can get some some GI discomfort, some bloating, some gas, etc.

There's a natural product alternative called raducose, which has been studied in humans.

And you can see these curves here on the graph is this is the placebo group in red.

And this is the change in blood glucose levels on the left in millimoles per liter.

This is how much time from the time of consumption of both the product, the supplement, and a glucose load of 75 grams.

And this is also the change in insulin on the right.

So you can see that both the insulin response and the glycemic response has been blunted.

So you're blunting the excursion, that big spike in both insulin and glucose, which is part of the reason that the researchers speculate A-carbose was able to expand the lifespan by up to 22% in male mice and about 5% in female mice, which is not uncommon to get differences in males and females, in median lifespan.

Part of it is being able to keep that glycemic excursion in a very tight, narrow range.

So we're able to essentially mimic that using this natural product alternative.

It's an extract from white mulberry leaves called Reducos.

The other ingredient that we're able to sneak into the, you know, sort of the NMN.

I was surprised to find this ingredient there.

And, you know, Spermidine has gotten a incredible revival as a pro longevity molecule here.

So it was like, yes, okay, I'm super excited that's there.

Yeah, And you know, Peter, we're excited about spermidine too, so much so that we're actually running some trials and preclinical models combining NAD3 with spermidine to see if there's some added benefit.

We're also adding spermine as well into that as a complex.

So we'll see what the results of that are in the in the near future.

But what what we did here is yeah, we're essentially using NMN as a Trojan horse, let's face it, right.

And we're able to sneak in some spermidine in here as well.

You can see it's polyamine because it has 3 amine groups here 123 on the molecule.

You know, they're important in DNA repair, they're important in DNA replication, cell cycle replication and maintenance.

They're also 1 of the mechanisms is we find it here, there's a nice big slide on multiple mechanisms is autophagy.

So it actually helps to inhibit mTOR a little bit, and it increases AMPK activation to amplify autophagy signaling.

It also helps with increasing potentially what we call protein translation in fidelity.

There's an area in geroscience in the pharma space where they're exploring what happens when you slow down the translation of mRNA to protein in the cell is you create less errors because there's a certain, you know, accepted error rate in that translation.

And when you slow it down, you're able to potentially decrease the amount of proteins that are translated aberrantly to increase the quality of protein translation.

And it's also potentially helping with apoptosis in programmed cell death, just making sure that it regulates the way that a cell behaves generally.

And there's also human data, which I think has flown under the radar.

Everyone thinks, oh, spermidine is, it's only been studied in fruit flies and worms, C.

Pekar et al in 2020 published an N of 85 study.

Granted, there was no placebo control, but there was a randomization into 1.9 milligrams or 3.3 milligrams.

And these were in 60 to 96-year-olds that already had some mild dementia diagnosis.

And it actually increased verbal fluency, verbal fluidity, and phonemic and phenometic fluidity as well.

So I think there's some exciting work that's still ahead of spermidine and where it's going.

I think it's gonna see a pretty interesting run is what I predict, at least in the next few years.

Joel Seidenberg And so I think we'll end with this, Peter, is basically, I think by now, your listeners has probably seen, well, it seems pretty clear that peak health span and peak NMN, not only were they formulated to be companion ingredients, but they sort of amplify each other in multiple ways.

So it's really not just like a jab, right cross, it's almost like a left hook, right cross, you know, I think they're both very powerful.

They both support the increase in NAD status in your cells, if people are interested in that.

And we're trying to fill the gaps and any of the limitations as well.

We're trying to address any of the limitations currently based on what we know in the latest state of the science.

We're trying to create a signature that mimics healthy lifespan promoting activities with this combination.

I think we've done a pretty good job at that.

Fantastic, a few last questions on the peak NMN product.

Again, your numbers are based on 3 capsules a day.

How do you recommend, is this something that a person can start with 3?

And then what's the best time of day to take this?

This 1, I do recommend that you break up those 3 capsules.

So you can start with 3 capsules, but I recommend breaking them up more in the PM side of your day.

So as opposed to the beginning where you've already bookended that in the middle of the day to the end of your day.

So you could do 2 capsules with your largest meal, for example, it's a good idea, because you're able to decrease that normal excursion or that spike in insulin and glycemia that you're normally gonna expect after a large meal.

And then maybe 1 more capsule as well, whether that be at lunch or dinner.

So we've covered in the last 3 videos, peak rise, sort of engage your brain, when the morning, when the day, peak health span and out peak NMN.

And for me, I really wanted to have these conversations with you so people could understand why there are numerous components here and how they play together and the logic and thinking of what you've created and structured here.

And again, full disclosure, both Hector and I are involved in LifeForce because we believe in it.

And hopefully this gives you some structured thinking about the supplements you're taking if you're interested in increasing your vitality and increasing your longevity.

And again, for me, this is the most extraordinary time ever to be alive.

And I wanna see every second that I possibly can.

Thank you for your time, for your brilliance.

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Lifeforce Nutraceuticals Explained: Peak NMN™️ | Ft. Dr. Peter Diamandis and Dr. Hector Lopez