In this episode Sal, Adam & Justin speak with hormone and peptide expert, Dr. William Seeds about the amazing healing properties of BPC 157.
   What’s the connection between BPC 157 and GHRP (Growth Hormone Release peptides)? (2:29)
   Bodybuilders and IGF-1 (Insulin-like Growth Factor 1). (9:08)
   Don’t get caught up in measuring IGF-1. (13:08)
   Any worries with Growth Hormone-Releasing Hormone (GHRH) regarding insulin sensitivity? (16:51)
   If you don’t have muscle mass everything is going to go wrong. (21:09)
   MK-0667 (Ibutamoren mesylate) benefits. (25:03)
   The difference between oral vs injection as the delivery method for BP 157. (30:25)
   How BPC 157 improves your body cells to do what they normally do. (36:08)
   Does BPC 157 help modulate cancer? (38:37)
   How collagen can enhance healing. (47:17)
   The areas of the body that BPC 157 is most beneficial. (50:00)
   Keeping up with his kids through fitness. (53:15)
   Related Links/Products Mentioned
   TRANSCEND your goals! Telehealth Provider • Physician Directed GET YOUR PERSONALIZED TREATMENT PLAN!  Hormone Replacement Therapy, Cognitive Function, Sleep & Fatigue, Athletic Performance and MORE. Their online process and medical experts make it simple to find out what’s right for you.
   Visit PRx Performance for an exclusive offer for Mind Pump listeners!
   July Promotion: MAPS Starter | MAPS Starter Bundle 50% off! **Code JULY50 at checkout**
   Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts
    Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial
   The Resistance Training Revolution – Book by Sal Di Stefano
    Boosting brain’s waste removal system could improve Alzheimer’s outcomes
   Senescence and cancer — role and therapeutic opportunities
   Mind Pump #2122: Deadlift Masterclass
   Mind Pump Podcast – YouTube
   Mind Pump Free Resources
   Featured Guest
   Dr. William Seeds (@williamseedsmd) Instagram
   Dr. William Seeds | Seeds.md
    

If you want to pump your body and expand your mind, there's only 1 place to go.

With your hosts, Sal DiStefano, Adam Schafer, and Justin Andrews.

You just found the world's number 1 fitness, health, and entertainment podcast.

He is the world's foremost authority on peptides.

In today's episode, we talk all about BPC-157, its value, its benefits, how to use it, how does it work in the body.

All of us have experienced it ourselves, so we know this is like legit.

By the way, if you're interested in working with peptides like BPC-157, Don't go online and buy a bunch of gray market crap.

Work with doctors and a real licensed pharmacy.

Go to mphormones.com and you can actually work with doctors and they work with peptides like BPC-157, so you know what you're getting and you get those actual results that you hear about, like in today's episode.

Now this episode is brought to you by some sponsors.

PRX Performance, this company makes home gym equipment that's as good or better than the stuff you use at your commercial gym, except it's designed to maximize space.

For example, they have a squat rack that folds into the wall.

It only comes off the wall less than 6 inches.

So you can literally equip your garage to be a gym.

Then you fold the squat rack very easily with 2 hands, very easy, into the wall.

Now you can park your car, but when you want, you got yourself a pretty sick gym in the garage.

By the way, you can make payments on their equipment, so it's like paying a gym membership, except again, you work out at home.

Go to prxperformance.com forward slash mind pump.

Also, we're running a sale on some workout programs.

This is our beginner strength training program is half off.

And then we have a bundle that includes Maps Anabolic and Maps Prime, that's called the starter bundle, that's also half off.

You can find both at mapsfitnessproducts.com, but you have to use the code JULY50 for that discount.

I said, hey, I want to do an episode on this peptide because it's probably 1 of the widest, most widely used, I would say, peptides, just generally speaking.

You mentioned that you also wanted to talk about, if we were gonna talk about BPC, GHRP peptides, growth hormone releasing peptides as well.

Why talk about growth hormone releasing peptides and BPC-157 in the same podcast?

Well, and more so, I think, following the concept of what you guys are behind.

BPC-157 is more of a recovery repair type of peptide.

It's a peptide focused on, and I think it has that purpose and serves that purpose best in recovery and repair and for injury or for training.

And in combining, so what I was talking about were GHRHs and GHRPs.

So growth hormone releasing hormone, growth hormone releasing peptides.

So there's the GHRHs are like the CJCs, the tesomerelin, the GHRPs are like the ipamerelin, the GHRP26, the MK0677, so they're different.

And I'll go through that again real quickly.

But what I was trying to say is that that platform of those type of peptides together, I think you could, I could do fine if I could tell you, and it's actually where I started, you could change most everything as far as efficiency in the cell for most people with just those 3 peptides.

If you just had those in your armatarium and in your toolbox in combination with diet, exercise, sleep, all the things that are, you know, we find important, you're going to just, you're going to change people's lives for the better and you're gonna improve cytoprotection of cells and you're gonna improve efficiencies of the cell.

And BPC work in the CJC epinephrines, those things work well because BPC will increase growth hormone receptors on cells and enhance what you're doing with the GHRHs and GHRPs because you're trying to, you're trying to, you're trying to make the most out of these signaling agents you can.

And 1 of the, I think 1 of the significant, and the GHRHs, GHRPs, they enhance androgen receptors on cells.

So they'll make your androgens work better.

So BPC upregulates growth hormone receptors.

So for people listening, growth hormone attaches to a receptor.

BPC increases the number of those receptors.

So now whatever growth hormone you have becomes more effective in essence.

And then the GHRs and GHRPs, these growth hormone releasing type peptides or compounds, they upregulate androgen receptors, which is what testosterone attaches to.

So there's a synergistic, very synergistic effect.

I'm like, okay, we're setting this platform for you to take advantage of all the things you're doing right or doing well.

And to make, you know, my, my belief in, in improvement in, in training, of lifting or athleticism is always maybe not the specific exercise at the time because all those things keep changing.

It's actually the recovery and repair in between that differentiates people that really can accelerate and that want to continue and makes the most out of how muscle breaks down and how it rebuilds.

And those 3 peptides are focused exactly on that because the downstream receptor, so you're using BPC, that is improving some other growth receptors and other growth factors in the cell, in particular increasing the growth hormone receptor.

You're using these GHR agents, GHRPs, to improve the physiologic release of growth hormone.

Plus they have their own receptors they work on, which I can get into.

But let's just say, now you've got your receptors working better, you've got growth hormone that's getting to the cell better.

Well, that's creating the environment to improve the IGF-1 production, which is the downstream product of growth hormone, which is IGF-1 is like the key to maturation, proliferation, differentiation of like myoblasts or muscle cells.

You know, when you work out and you break down a muscle, you have satellite cells that sit around this thing called the sarcolemma and these satellite cells by the action of trauma, they are activated.

And they actually release a, they release their own IGF-1EC, which is known as mechanical growth factor, MGF.

People probably don't know that peptide, it's MGF.

That creates the ability to start changing that satellite cell, which is stem cell, into a myoblast, and then those myoblasts fuse to the muscle fibers to rebuild.

I just read a study on that, by the way, where the speculation was on hyperplasia, but they saw a study and said, oh no, they're actually fusing.

But that's awesome that you, that's awesome.

And- You're making muscle fibers like bigger by fusing with other, rather than creating more muscle.

I just read that study is pretty remarkable.

So does that debunk our thought process around what happens to some of these like massive bodybuilders from

Their muscle fibers just become rather than creating more muscle fibers, which is what people thought hyperplasia, you're just making them permanently bigger to some extent.

Correct, and they're just very, they're significantly hypertrophied.

But you're adding, you can make, you can, to some degree, you can make more, you can make some more Myoblast.

You can build some, but it's incremental.

And it, you know, those guys, those massive changes happen, just don't happen overnight.

Yeah, so it happens, but it's all about, so what I was trying to say is that downstream IGF-1, that's really the key from growth hormone.

It's 1 of the key players in recovery and repair of muscle.

IGF-1, it's insulin-like growth factor, right?

That's the, when people talk about the muscle building effects or potential of growth hormone, right?

Really, it's not the growth hormone, it's the IGF-1 that's causing all that.

hormone, but that causes your liver to produce more IGF-1.

So the growth hormone starts, it starts this incredible cascade of other biochemical pathways.

So it's, remember the thing I talked about AMPK?

So it starts that activation of AMPK that will start this process of influencing PGC1 alpha, that influences another factor that is for mitochondrial biogenesis.

It's for increasing mitochondria, it's for improving fat oxidation.

It like starts doing all these things that are what?

Catabolic, that start cleaning up a cell, But then it also goes down this pathway of producing IGF-1 that's all about building and working with building and with the activation of mTOR down the road.

So It's a concert, it's an orchestra that works together.

In the, because bodybuilders have always been the, I mean, they're the experimental cosmonauts, right?

They're the ones that go out and just do crazy stuff, experiment on themselves, And then you get a bunch of anecdote and sometimes they're wrong.

Sometimes there's quite a bit of insight, which is really interesting.

They'll always talk about how, well, growth hormone doesn't really, it builds muscle when your testosterone is really high.

Is it that synergistic effect where the IGF-1 is improving the potential for this proliferation, but you need the signaling from the testosterone to really make it happen?

Or is it just so subtle that unless your testosterone is there, you're not gonna see a huge effect.

The IGF-1 is, none of this happens unless you're stressing the muscle.

So you could take all the testosterone you want and all IGF-1 and not.

If you take too much, you'll get, you know, those turtle stomachs and stuff that people don't know they get because they're taking too much IGF-1 by themselves or growth hormone, they're super physiologic doses.

But they, You have to have the stress mechanisms of the weight training to make those things work.

Now, how significant is the rise in IGF-1 in a typical healthy individual who takes, let's say, Ibutamorin or CJC, or like, what does it look like when you're measuring?

And are there people who are non-responders?

I've heard this, where some people take these things and just nothing happens to the IGF-1, or is that a myth?

So that's where people get caught up in the measuring.

If you're measuring IGF-1, you're just gonna lose on this because it's a very quick response.

It's a physiologic response, meaning you're not gonna really, You're getting enough in the cell to do its work.

You're not necessarily making the liver pump out a ton of IGF-1 itself.

Most of the things like, all the iso, IGF-1 divides into 3 isoforms, IGF-1A, IGF-1E, IGF-1A, IGF-1EB, and IGF-1EC.

EC is like mechanical growth factor, But what those are, those are just all little isoforms that are active in growth and maturation, proliferation of cells that are local in a cell.

They're local like in the satellite cell and the muscle cells that are released that make things happen.

It's not like you're sending a signal and the liver's making all this IGF-1 and it's going out throughout the body.

That occurs if you're going above physiologic levels of growth hormone or you're using exogenous growth hormone or you're using IGF-1 by itself as a peptide, which you can use to enhance muscle growth and injury repair.

Then you're going to raise levels, serum levels of IGF-1.

So what I'm saying is physiologic releases of IGF-1 are just, they're there when you need it, and it's not like you're sustaining these high levels.

They're not going beyond a super physiologic level.

So people get caught up in trying to, like I've had arguments.

Compared to taking growth hormone or something.

Like people get caught up because it compared to like.

You're not gonna, if you're taking growth hormone, you're gonna increase, you know, you're gonna increase your IGF-1 levels because you're constantly bleeding growth hormone.

There's no, growth hormone's meant to be pulsed.

It's meant to be pulsed throughout the day, biggest pulse at night.

It can be anywhere from 3 to 6 to 8 pulses in some people, but it's meant to be pulsed every 3 hours.

When you take exogenous growth hormone, that means it's stimulating 24 7.

You've all of a sudden got this growth hormone in that, and that's what causes like negative feedback issues and all these causes cell senescence.

It causes all of these problems that people have no idea that's happening when they're using it.

But that release of growth, So then you're not pulsing, you're just getting constant stimulation of that growth hormone receptor that's making IGF-1 continuously.

So you're gonna get a rise in IGF-1 that's gonna be super physiologic, that you're gonna see in the serum in the blood.

Are there any worries with anything that, you know, growth hormone releasers or growth hormone-releasing peptides in regards to insulin sensitivity or issues with blood sugar?

Because I know that growth hormone and insulin, I don't know, they're somewhat inversely related, right?

Like you don't want, if you're, people with Disorders where they produce too much growth hormone tend to become diabetic.

If people who have lots of insulin tend to have really low growth hormone.

Is there any worry that if I go on 1 of these and I take them, that I could develop issues with insulin sensitivity?

No, and in fact, the best studies have been in the, specifically with AIDS patients that have significant lipodystrophy where they have incredible amount of fat around their organs and-

Tessameruline specifically is for them, right?

That's where all the research from tessamorelin came from AIDS.

And what you're doing with a growth hormone releasing hormone or a GHRH like tesmerelin is you're really setting, so 1 of the pathways we didn't talk about is you're setting the cell up to not utilize glucose but to utilize fat as its primary substrate or it's for oxidation to make ATP basically to make energy.

And so you're up, you're getting that system back on track, basically, again, these are, you can always look at these as modulators because what they're doing is just letting the cell get back to where it was again.

And that's what tesomeralin is help, it shows that you're utilizing fat as its oxidative substrate to make ATP.

So in the beginning, like when people use tesamoralin, they may sometimes see their glucose might be a little higher for a little bit, or they may have more, they're just starting to use their fat.

It's like, it's a little counterintuitive, but you want more fat to utilize fat, but in order to utilize more fat, you have to make more mitochondria.

Well, the GHRH is, remember what I told you, that pathway, AMPK to PGC1 alpha, to start the cell to transcribe more mitochondrial biogenesis to make more mitochondria?

You're making more mitochondria to use more fat.

So you're catching up eventually to start.

So initially you'll see higher glucose a little bit because you're using more fat, but then the mitochondria catch up and then you're okay.

Yeah, it can happen with people just doing GHR, like CJC and epimoralin, they can see things like that at the beginning.

And that's why you don't get hooked into looking at those parameters.

You've got to think about what are you doing down the road to improve insulin sensitivity?

Because what you're doing, what does exercise do?

So like diabetics that are insulin resistant, right?

Muscle is your biggest endocrine gland, it needs glucose.

Well, exercise turns off that mechanism and it transports this GLUT4 transporter to the muscle that just brings glucose in with exercise.

Well, the GLP1 or the GHRHs, GHRPs, they activate something called AMPK, and AMPK activates those glute force to go to the cell to pull in glucose too.

So it's like an exercise mimetic, but it's doing what exercise does, but it's doing the same thing.

By the way, this is why strength training is the most effective form of exercise in terms of insulin sensitivity.

You just have larger, you know, basically storage capacity.

And you increase all those GLUT4 receptors like crazy.

Well, it's what it's you know, it's great.

I don't know why now all of a sudden now strength training's becoming a real important in health.

Well, have you heard of this podcast called Mind Pump?

We're trying real hard to promote it that way.

I think we're making some headway, maybe.

I mean, well, Sal wrote that book, what almost, has it been 3

3 years ago called the Resistance Training Revolution.

And that was the idea behind it was that.

Because, right, I mean, I don't care if you can go out and run 2 miles or 5 miles or okay, great, but can you show me how many, can you get off the floor?

You know, can you, I mean, it's all about functionality and strength.

And I can tell you from a whole different perspective, you know, by the way, I'm also an orthopedic surgeon, I'm sports trained, joint trained, and I see all those people who say, hey, doc, where are my golden years go?

I've worked so hard for 30 years and I can't even walk with my wife down the street.

And I saw that when as a younger physician, day after day, and I was just like, what is wrong?

Well, it's the difference between catabolic exercise and anabolic exercise.

And so strength training is pro-tissue and that's the tissue that we just saw.

I mean, sarcopenia is, I mean, it's everywhere now.

That's like the, it's well, yeah, it's, if you don't have muscle mass, everything's going to go wrong.

I mean, it's, you gotta, I can, I just, you gotta have muscle?

You know, that's where all the science right now, we're, we're, I, it's incredible where we are with looking at these things called myokines and exokines that are actually produced by strength training, by resistance training.

And in fact, 1 of the bigger fields right now looking at this is cancer research, because there are these myokines that are being made that actually, that act as inhibitors of certain processes that will propagate cancer or metastasis of cancer.

And that's, that's a whole, that's incredible that you got to get to this point to convince people how important strength training is, you know, to, you got to get it to that state to show people like,

Like these are athletes that just pump themselves full

See all Mind Pump: Raw Fitness Truth transcripts on Applepodcasts

2125: Heal Like Wolverine: BPC 157 with Dr. William Seeds